Shopping Cart

Your shopping cart is currently empty

Palonosetron hydrochloride

Name: Palonosetron hydrochloride
Brand: TargetMol
SKU: T1156
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1156Cas No. 135729-62-3

Alias RS-25259-197, RS 25259, Palonosetron HCl

Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Palonosetron hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.92%

Catalog No. T1156Alias RS-25259-197, RS 25259, Palonosetron HClCas No. 135729-62-3

Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$77	In Stock	In Stock
500 mg	$198	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
In vivo	Palonosetron exhibits a longer plasma half-life of approximately 40 hours compared to other antagonists in its class (ondansetron, 4 hours; tropisetron, 7.3 hours; dolasetron, 7.5 hours; ranisetron, 8.9 hours). Additionally, it demonstrates a hundredfold greater binding affinity to the 5-HT3 receptor, with a pKi of 10.5, which is significantly higher than that of granisetron (pKi 8.91), tropisetron (pKi 8.81), ondansetron (pKi 8.39), and dolasetron (pKi 7.6).
Synonyms	RS-25259-197, RS 25259, Palonosetron HCl

Chemical Properties

Molecular Weight	332.87
Formula	C₁₉H₂₄N₂O·HCl
Cas No.	135729-62-3
Smiles	Cl.O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (300.42 mM), Sonication is recommended.

DMSO: 3.33 mg/mL (10 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.0042 mL	15.0209 mL	30.0418 mL	150.2088 mL
5 mM	0.6008 mL	3.0042 mL	6.0084 mL	30.0418 mL
10 mM	0.3004 mL	1.5021 mL	3.0042 mL	15.0209 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1502 mL	0.7510 mL	1.5021 mL	7.5104 mL
50 mM	0.0601 mL	0.3004 mL	0.6008 mL	3.0042 mL
100 mM	0.0300 mL	0.1502 mL	0.3004 mL	1.5021 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc